First of all, are we talking standard vSwitches here or do you have Enterprise+ licenses allowing for distributed vSwitches?
- 4 physical nics for the connection of the client network (VLAN 50)
I don't know about the workloads, but are you sure you need the bandwidth of that many links for VM traffic?
- 4 physical nics for vmotion, NFS and ISCSI (VLAN 100)
- 2 physical nics for the management network and service console (VLAN 101)
Do not put vMotion and anything else, especially not IP-storage on the same VLAN or the same physical NICs either.
I'd just put vMotion on the same 2 NIC team as management, on a separate isolated VLAN.
Will you really be using both, NFS and iSCSI or are you unsure there yet? Again I don't know about the workloads, but you can consider going with 2 NICs only for storage, especially in the case of NFS as it's not capable of proper load balancing/multipathing.